We stayed at Hotel Sant'Angelo for two nights. We actually booked through Hotels.com. It was in a great location near Vatican City but not too far away from the Colosseum/Forum area. The staff was incredibly helpful and friendly. The room was clean and actually really nice. It was decorated with antiques and had kind of a castle vibe. They had free breakfast but we had to leave really early both days we were there so I can't say how that is.
There is honestly actually only one bad thing I can say about this hotel. The shower in our bathroom was tiny. I'm only 5'3 and 110 pounds. I could barely move in the shower. I had to do some impressive acrobatics just to be able to shave my legs. And some SUPER impressive acrobatics when I accidentally dropped my razor! I have no idea how Philip was even able to wash himself in that shower (he's 6'0 and 175 pounds).
Pros: Clean, Great Location, Friendly Staff, Good Vibe, Free Breakfast
Cons: Tiny Shower
Even though showering in the morning was a hassle, I still give this hotel a 4 out of 5. I'd definitely recommend it. Just keep that tiny shower in mind if you're a large person!